I've used Sentinel for at least 14 years and it works well. There was a few months it wasn't available due to the production plant but other than that have used it exclusively except for three times when I had to do a topical for ticks. When it first came out I never saw a live tick on the dogs even though it was for fleas and worms. The last few years either the ticks are more resistant or the formula has changed a bit as a couple of times I've had to topically treat for seed ticks. UGH!!!. We have a very high deer population so deer are everywhere day and night. Yesterday afternoon I saw a herd of about 20 run across the yard behind us. It has also been on the market a lot longer than some of the newer preventatives. You can read the differences below. The information does not mention which other worms it controls but it is all but flea tape worms. Be very careful of ordering online as lots of fake meds out there.
Sentinel vs. Trifexis
Both Sentinel and Trifexis had the same medication (milbemycin oxime) for Heartworm and Intestinal Parasite prevention, and both are chewable flavored tablets. The difference is in the flea prevention.
Sentinel contains lufenuron, which is an IGR - or insect growth regulator. Sentinel does not kill fleas, but it essentually sterilizes the adult flea, and any eggs produced are unable to hatch, which means you never get a flea infestation. We generally recommend Sentinel as our #1 Heartworm and flea prevention, if you are not seeing many fleas with your dog, or if your dog has a history of seizures. (
http://www.sentinelpet.com)
Trifexis on the other hand, contains spinosad. Spinosad kills the adult flea before it can reproduce, so therefore ending a flea infestation before it can begin. Generally we use Trifexis with dogs who may come in more frequent contact with fleas, have a flea sensitivity, or have an ongoing flea problem. (
http://www.trifexis.com)
Here is an added mote about HeartGuard that is very important. I found the information here. The site also reviews other brands and warns against one called B-Mectin.
http://www.dogsbynina.com/best-nail-cli ... heartgard/HeartGard has been proven to be safe in most breeds of dogs. I say most because there is a warning about giving this medication to herding breeds.
Herding breeds such as collies and shepherds are more sensitive to the active ingredient in HeartGard called Ivermectin. This is due to MDR1 gene. This is surprisingly not listed on the HeartGard website though they do have a lot of information on 1-800-PETMEDS website.
If your dog falls into the category of herding breeds then you should consult with your vet before choosing HeartGard as your heartworm preventative. You may need to choose a brand that uses a different active ingredient.